Alouatta PROJECT
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Genomics and Genetics of the Howler Monkeys
ONGOING Approaches
Phylogenomics & Sex-chromosome Evolution
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Using different next-gen tecnologies we intend to produce high quality reference genomes for the Alouatta species to increase accuracy of phylogenetic relationships between the different species; study chromosome number evolution, especially the evolution of multiple XY systems through y-autosome translocations; and to raise single genome demographic inferences, focusing on differences in effective population sizes between endangered and non-endangered species, and differences in sex-specific effective size due to polygyny and mating structure.
Hybridization and Immunity
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Based on reference genomes, besides draft ones, we aiming to investigate hybridization and immunity issues into an evolutionary and conservation context,
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Performing demographic reconstruction, focusing on patterns of hybridization and possible reproductive barriers
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Studying structural variation and its role in hybridization, especially on the sex chromosomes;
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Implementing population genetic analysis of disease adaptation, especially diversity and selection in immune related genes, toll-like receptors, and malaria interacting proteins
Molecular Taxonomic Units
Using mitochondrial markers and also nuclear genes we are performing molecular species-delimitation analyses and DNA barcoding in order to identify MOTUs (Molecular Taxonomic Units) and clarify issues related to hidden biodiversity and inter- and intra-specific genetic relationships in the genus
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Population Genomics and Genetics
Using genotyping by sequencing, besides microsatellite and mitochondrial markers, we are investigating genetic diversity and structure to infer on population and demographic issues, such as gene flow, matrilinear structure, kinship, parentage, inbreeding, etc.